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Post by c on Feb 3, 2021 21:47:09 GMT
Could be wrong but the non-mRNA vaccines also do not require refrigeration, which makes getting them out a lot faster and cheaper.
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Post by iNCY on Feb 3, 2021 23:51:50 GMT
And just like that, for Victoria masks are back for all indoors, this also means the cap on private gatherings in homes will be reduced from 30 to 15 people, and the expanded office capacity due to be introduced on Monday is on pause. Because of one guy. Because we've made exceptions for the Australian Tennis Open. Oh come on, the issue is not with the Australian open, it is the fact that the system obviously broke down. In Perth it turns out that security guards weren't mandated to wear masks and here we obviously had a break down in the system somehow. This is the world we live in now.
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Post by c on Feb 9, 2021 5:29:46 GMT
501Y.V2 mutation, South African COVID variant, is bypassing the Oxford vaccine. Seems to cut the other vaccines effectiveness to about half as well.
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Post by Deleted on Feb 9, 2021 10:44:51 GMT
501Y.V2 mutation, South African COVID variant, is bypassing the Oxford vaccine. Seems to cut the other vaccines effectiveness to about half as well. As with most sweeping statements c makes, there are caveats: - This is a very small sample size of 2000 people with huge confidence intervals. Expected efficacy is in line with J & J which is diminished but not 'bypassed'. - This was a sub-sample of the initial SA trial using the old, less-effective dosing regimen of four weeks between doses. - The SA variant is not more infectious than the UK variant, therefore it will not naturally dominate until the vaccine has become widely effective against the UK variant. So it's going to be months until the SA variant runs rampant. - And most importantly of all, remember that this is only relating to symptomatic cases. So if have a little cough for a week, the vaccine is deemed to have not worked on you, when in reality it may have saved your life. We are much more interested in how the vaccine prevents severe illness, and there is huge confidence that it still will.
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Post by c on Feb 10, 2021 0:37:25 GMT
Talk now of super mutators. Basically immunocompromised people can become super mutators allowing the virus to undergo rapid mutation because the body cannot fight off the infection. In these cases the people develop several different strain within their bodies and in the Boston case, the man was showing signs that the virus was rapidly adapting to treatment. This gives a good theory for how a novel mutation emerges in the population and why the virus appears to be stable, until it is not basically. Also seeing what appears to be convergent evolution, which is amazing to see in the wild as it is a fairly speculative theory. www.npr.org/sections/goatsandsoda/2021/02/05/964447070/where-did-the-coronavirus-variants-come-fromAnd that South African variant shows that the vaccine may not be a one and done fix to the COVID crisis. Which is something people will need to know, as it is likely when the current vaccines fail people will be less likely to get a second one, which will extend the crisis more despite this being how treating viruses work. We knock down one strain, then adapt the vaccines to the novel versions. It is likely we will need yearly boosters for COVID to stay ahead of it. Not a problem for most of the world, but in the US, the anti-vax movement is strong and people even getting one COVID vaccine shot is not assured for 30% of the population. For the rest of the world, that group will be your mutators. Attitudes in the US are that the vaccine will end the COVID crisis here in the states when most people get it and the US will return to normal in the summer. This is not looking to be the case right now.
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Post by c on Feb 10, 2021 4:38:59 GMT
FDA approved the Eli Lilly antibody bomb of bamlanivimab and etesevimab for emergency use. They expect in the next four months to pump out 750k doses. Sadly these likely in the US will be a "not for you" medication as they are often used as a early treatment, and for most normal people treatment starts after COVID progresses to the point of hospitalization.
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Post by System on Feb 10, 2021 6:26:33 GMT
I know if I cared so much about Covid I wouldn’t be travelling but if you’re a flight attendant you should know MASK OVER NOSE. Flew into Gold Coast today and flight attendant had the under the nose gimmick going all flight.
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Post by Deleted on Feb 10, 2021 12:02:18 GMT
The super mutator stuff is absolutely fascinating, and makes sense. Fortunately I would imagine most countries will vaccinate these people as a matter of priority considering their mortality risk. Even if the vaccine is not completely effect, if it can just galvanise a few T-cells to put some pressure on the virus, the vaccine itself should suppress the ability of these super mutators to host mutations.
There will definitely be some sort of boost this winter. I don't know about forever. There will be a lot of T-cell cross-immunity with other variants. Unless the coronavirus changes to become something more like the flu (which isn't going to happen), eventually all of the pressure put on the virus by vaccines will tell. Eradication hopes will depend on the virus' ability to evolve once most people are vaccinated, so time will tell, but for now the most important thing is that the vast majority of people at risk of dying will stop dying.
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Post by c on Feb 10, 2021 15:59:54 GMT
I have a few friends with autoimmune diseases and the only person so far that qualified for the vaccine in the US got her because she works in healthcare. No prioritization here. Looks like there is rare but serious side effect of the vaccines in thrombocytopenia. Basically in rare cases it causes the platelet counts to bottom out. Article on it in preparation, but not enough data really to do anything but advise doctors to report. www.nytimes.com/2021/02/08/health/immune-thrombocytopenia-covid-vaccine-blood.html
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Post by Deleted on Feb 10, 2021 20:33:30 GMT
This paper may uncover the sudden confidence everybody has in protection against the South African variant of interest: www.researchsquare.com/article/rs-226857/v1Discard the headline. They set out to compare immunity induced by vaccination with immunity induced by infection and did a pretty terrible job of it. But what it does prove is that T-cell response was intact even though potent antibodies in some cases were not. It's inferred then that there is extreme likelihood that T-cell immunity induced by vaccines exhibiting the original spike protein will be triggered by the South African variant. In simple terms, more people will get mild symptoms, but there is no expectation that more people will require oxygen or die. Today, the WHO has encouraged countries to follow the UK's approach to use the AstraZeneca jab on all age groups and with the extended 12 week gap between doses. Data is due to be released in the next few days that according to a major British newspaper shows Pfizer and AstraZeneca are both extremely effective at preventing any symptomatic infection whatsoever in over 65s.
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Post by c on Feb 10, 2021 23:39:10 GMT
Not sure they have the data to make that claim, but it could be expected that some cross protection will exist with new strains. The problem with mutations so far is not that the mutations themselves, but fear of a black swan event where the virus mutates and spreads breaking the vaccines. Unlike many other fields that would say the chances of that happening are too low care about, medicine wants to stay ahead of this. There is a problem of overconfidence though. We seen in with the flu where some seasons the flu shrugs off the vaccine and starts killing people rapidly.
I do question people who believe this will be eradicated in the near future too. We still have not eradicated Malaria or Polio and eradication of Rubella and Measles both failed to antivax movements.
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Post by Deleted on Feb 11, 2021 0:13:59 GMT
Not sure they have the data to make that claim, but it could be expected that some cross protection will exist with new strains. The problem with mutations so far is not that the mutations themselves, but fear of a black swan event where the virus mutates and spreads breaking the vaccines. Unlike many other fields that would say the chances of that happening are too low care about, medicine wants to stay ahead of this. There is a problem of overconfidence though. We seen in with the flu where some seasons the flu shrugs off the vaccine and starts killing people rapidly. I agree with what you're saying. The nightmare scenario with this is that it becomes like the flu. It seems unlikely. It's rate of mutation is much lower, but you never know. I agree eradication is difficult, but I have issues with some of your examples. Polio is 99% eradicated, which yes is not total eradication, but basically means in almost every corner of the world you can't get it. Rubella is basically eradicated in the first world. Measles has an r0 of about 15. Malaria is parasitic and therefore much more prone to evolving drug resistance. So in terms of total global eradication, yes, an r0 of between 4 and 8 and a high rate of pre-symptomatic spread will mean vaccine uptake will need to be extremely high to eradicate fully. Plus luck will be needed as far as mutations go.
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Post by c on Feb 11, 2021 0:46:49 GMT
Both measles and rubella were set to be eradicated by 2020 and we nearly made it. But the last 2000's anti-vax movement fucked it all up. Now measles deaths are soaring and it is a matter of time before rubella returns to the west it is assumed.
Polio is nearly finished though. Types 2 and 3 are believed to be eradicated. Type 1 appears limited to the Pakistan / Afghanistan border. Real soon at least wild polio will be eradicated. The vaccine induced polio still needs fighting but the main outbreak seems limited to the Congo region. So damn close.
Timeline for Malaria is eradication by 2050. The science is a bit weird, but mass cullings of the mosquitoes greatly cut back on infection rates.
Nearly eradicated the lesser known Yaws as well. Ancient disease that is discussed in classical medical texts.
We abandoned the Syphilis eradication. Got very close to eradicating the Great Pox, but it reared back hard in the 2000's via the gay community in the South.
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Legend
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Post by The Kid on Feb 11, 2021 0:53:10 GMT
Oh by the way.
I got my second vaccine shot Monday. Arm was killing me the next day. Still hurts today including my arm pit area. My wife felt worse the day after. Chills and body aches. I got it pretty easy. I’m officially vaccinated.
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Legend
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Post by 🤯 on Feb 11, 2021 1:11:13 GMT
Oh by the way. I got my second vaccine shot Monday. Arm was killing me the next day. Still hurts today including my arm pit area. My wife felt worse the day after. Chills and body aches. I got it pretty easy. I’m officially vaccinated. Congratulations on your vasectomy.
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Legend
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Post by 🤯 on Feb 11, 2021 1:12:10 GMT
Oh wrong thread
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Legend
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Post by Ness on Feb 11, 2021 1:32:20 GMT
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Legend
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Post by The Kid on Feb 11, 2021 1:36:01 GMT
Well this place is hostile and non comforting. 😂
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Legend
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Post by 🤯 on Feb 11, 2021 1:36:46 GMT
Talk about the circle of life
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Legend
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Post by 🤯 on Feb 11, 2021 1:37:06 GMT
Well this place is hostile and non comforting. 😂 Just jealous of your gains
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God
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Post by iNCY on Feb 11, 2021 2:03:18 GMT
Oh by the way. I got my second vaccine shot Monday. Arm was killing me the next day. Still hurts today including my arm pit area. My wife felt worse the day after. Chills and body aches. I got it pretty easy. I’m officially vaccinated. Congratulations on your vasectomy. The major concern with the vaccine side-effects is that it may impair the placenta forming in women. Hence the new world order of population control and a universalist government of a socialist dictatorship will be enacted... Well the first line is a legitimate concern anyway... But, then again.... 🤨
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Legend
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Post by c on Feb 11, 2021 2:18:10 GMT
That study dealt with COVID itself not the vaccine. And it was not replicated and generally dismissed now that there is a much larger number of births during the COVID era to work with.
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Legend
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Post by nath45 on Feb 12, 2021 8:01:09 GMT
All of Victoria, Australia is now back in stage 4 lockdown. All of Victoria. Because of 5 cases. 5 cases in Melbourne.
Cue panic buying. Cue panic attacks. This is 'storm the Capitol' levels of fuck you.
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God
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Post by iNCY on Feb 12, 2021 8:20:00 GMT
All of Victoria, Australia is now back in stage 4 lockdown. All of Victoria. Because of 5 cases. 5 cases in Melbourne. Cue panic buying. Cue panic attacks. This is 'storm the Capitol' levels of fuck you. #SackDanAndrews
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God
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Post by System on Feb 12, 2021 13:03:50 GMT
All of Victoria, Australia is now back in stage 4 lockdown. All of Victoria. Because of 5 cases. 5 cases in Melbourne. Cue panic buying. Cue panic attacks. This is 'storm the Capitol' levels of fuck you. They should really start giving supermarkets a heads up before they announce lockdowns. If I lived in Victoria in 2020/21 & had the means to do so I would have moved state.
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God
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Post by System on Feb 12, 2021 13:07:55 GMT
Congratulations on your vasectomy. The major concern with the vaccine side-effects is that it may impair the placenta forming in women. Hence the new world order of population control and a universalist government of a socialist dictatorship will be enacted... Well the first line is a legitimate concern anyway... But, then again.... 🤨 Can’t believe that was a legit video, alarming
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God
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Post by iNCY on Feb 12, 2021 13:57:40 GMT
The major concern with the vaccine side-effects is that it may impair the placenta forming in women. Hence the new world order of population control and a universalist government of a socialist dictatorship will be enacted... Well the first line is a legitimate concern anyway... But, then again.... 🤨 Can’t believe that was a legit video, alarming Welcome to the dark side
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Post by Deleted on Feb 12, 2021 15:26:42 GMT
According to Israel, real-world efficacy in preventing symptomatic infection is 93% in Pfizer.
Incredible.
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Post by iron maiden on Feb 12, 2021 15:55:14 GMT
Congratulations on your vasectomy. The major concern with the vaccine side-effects is that it may impair the placenta forming in women. Hence the new world order of population control and a universalist government of a socialist dictatorship will be enacted... Well the first line is a legitimate concern anyway... But, then again.... 🤨 Children of Men movie come to life.
I'm of the mind that those who take it will be far less sorry than those who don't.
Our government has done a shit job in dolling the vaccine out. We don't even have the large population of the UK and US. They've apparently vaccinated all/most of the elderly in long term care BUT not those who are in private facilities such as my mom's 99 year old lady. Some of the vaccine has actually been wasted due to poor planning and there are health care professionals who have lost their jobs over choosing to use the vaccine (vaccinated people who weren't on the agenda) instead of wasting it which only lends credibility to the naysayers and conspiracy theorists.
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Post by Deleted on Feb 12, 2021 16:04:14 GMT
They fired people for giving leftover jabs instead of throwing them away?
That's wild.
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